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    Browsing by Advisor "Varadarajan, Raghavan"

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      • Effects of Cyclic Permutation, Glycan Removal and Aspartate Mutagenesis on Conformation of HIV-1 Envelope 

        Das, Raksha
        It has been decades since Human Immunodeficiency Virus-1 (HIV-1) was discovered. The virus has created havoc worldwide. According to the UNAIDS 2014 Gap report, 35million people worldwide are infected with HIV-1 and yet ...
      • gp120 Immunogen Design And Characterization 

        Chakraborty, Kausik (2011-10-21)
        HIV-1 is the causative agent for AIDS and has been a major focus of research for the past two decades. Though there is a combination therapy in place known as the “Highly Active Anti-Retroviral Therapy” (HAART), its ...
      • HIV-1 and SARS-CoV-2 immunogen design 

        Malladi, Sameer Kumar
        Human Immunodeficiency Virus (HIV-1) is the aetiologic agent of AIDS. Presently there are ~38 million HIV-1 infected individuals worldwide and ~1 million deaths in 2019. Since its discovery, the quest for vaccine candidate ...
      • HIV-1 Immunogen Design : Envelope Protein Minimization, Stabilization and Glycan Removal 

        Rathore, Ujjwal
        Effective vaccines exist for a number of viral diseases. However, despite much effort, there is no successful vaccine against the Human Immunodeficiency Virus (HIV-1). The envelope glycoprotein (Env) of HIV-1 gp120, the ...
      • Interaction Of Chaperone SecB With Protein Substrates: A Biophysical Study 

        Panse, Vikram G (Indian Institute of Science, 2006-10-17)
        In the cell, as in in vitro, the final conformation of a protein is determined by it's amino acid sequence (1). Some isolated proteins can be denatured and refolded in vitro in absence of extrinsic factors. However, in ...
      • Mechanistic And Regulatory Aspects Of The Mycobacterium Tuberculosis Dephosphocoenzyme A Kinase 

        Walia, Guneet (2013-09-11)
        The current, grim world-TB scenario, with TB being the single largest infectious disease killer, warrants a more effective approach to tackle the deadly pathogen, Mycobacterium tuberculosis. The deadly synergy of this ...
      • Mechanistic insights into protein stabilization and protein-protein interactions 

        Chattopadhyay, Gopinath
        Most amino acid substitutions in a protein either lead to partial loss of function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue the defects caused by diverse loss ...
      • Modulation of Protein Stability and Function by Cysteine Mutations and Signal Peptides 

        Sharma, Likhesh (2018-06-23)
        Chapter 1gives a general introduction to the CXXC motif found in natural proteins. It then reviews the studies where disulphides were engineered in various proteins. The various strategies developed to engineer metal binding ...
      • Molecular Characterization of Mannose Binding Lectins 

        Nisha, G J
        Lectins are proteins of non-immunologic origin that bind to carbohydrates with high fidelity. They constitute a large class of multivalent recognition molecules that specifically interact with their cognate sugar moieties ...
      • Molecular Determinants of Mutant Phenotypes in the CcdAB Toxin -Antitoxin System 

        Guptha, Kritika (2018-05-29)
        A major challenge in biology is to understand and predict the effect of mutations on protein structure, stability and function. Chapter 1 provides a general introduction on protein sequence-structure relationships and use ...
      • Mutational sensitivity of CcdB mutants in their native operonic context 

        Bajaj, Priyanka
        Determining the precise effects of thousands of point mutants on protein structure, stability, and activity is a challenging task. Chapter 1 introduces how next-generation sequencing technologies exploit phenotypic screens ...
      • Probing Protein Sequence-Function Relationships using Deep Mutational Scanning 

        Chandra, Soumyanetra
        Deep Mutational Scanning (DMS) approaches help elucidate sequence-function-phenotype relationships in proteins, which ultimately improves our understanding of residue (or nucleotide)-specific contributions to protein ...
      • Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein 

        Kesavardana, Sannula (2018-05-09)
        A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease ...
      • Protein Engineering of HIV-1 Env and Human CD4 

        Saha, Piyali (2018-05-01)
        Since, its discovery over three decades ago, HIV has wrecked havoc worldwide. According to the UNAIDS report 2011, at present 34 million people is living with HIV and AIDS vaccine with broadly neutralizing activity still ...
      • Protein Minimization Of Human CD4 And Design Of gp120-CD4 Single Chain Immunogens 

        Sharma, Deepak Kumar (2011-10-19)
      • Protein Structure and Mutant Phenotype Prediction from Analysis of Mutant Libraries by Deep Sequencing 

        Khare, Shruti
        Proteins play a central role in all the biological processes. The immense diversity in protein structures and functions despite similar underlying composition is intriguing. The work presented in this thesis aims to provide ...
      • Rational Elicitation of Cold Sensitive Phenotypes 

        Chetana Baliga, B
        Conditional gene expression and conditional mutants provide a means to modulate the expression of specific genes and to control the activity of their protein products in vivo, so as to be able to study their effects on the ...
      • Role of autophagy in reducing peripheral neuropathy and diabetic peripheral neuropathy 

        Ramlal, Jaiswar Praveen
        Peripheral neuropathy occurs when there is damage to the central or peripheral nervous system due to injury, disease, diabetes, or drug use. Endoplasmic reticulum (ER) stress is a distinct feature observed in neuropathic ...
      • Scanning mutagenesis studies of HIV-1 Env immunogenicity and structure 

        Datta, Rohini
        Human Immunodeficiency Virus type 1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a global pandemic with 36.7 million people living with HIV-1 all over the world and approximately ...
      • Sequence Analysis And Design Of Immunogens From The Stem Domain Of Influenza Hemagglutinin 

        Bommakanti, Gayathri (2013-07-10)
        Influenza is an important respiratory pathogen that infects several million people each year. Currently available flu vaccines have to be updated regularly in order to be effective as the virus changes its composition by ...

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