Now showing items 1-10 of 152
Design and Characterization of HIV-1 ENV Derived Immunogens
The Human Immunodeficiency Virus (HIV) is a member of the retroviridae family from lentivirus genus which primarily infects CD4+ T cells and also to lesser degree monocytes, macrophages, and dendritic cells causing progressive ...
Molecular Characterization c-di-GMP Signalling In Mycobacterium Smegmatis
Bacterial stationary phase is an interesting biological system to study, as the organism undergoes several metabolic changes during this period and new molecules are generated to support its survival. The stationary phase ...
Estradiol Induced Changes In Neuronal Excitability And Neuron-Astrocyte Signaling In Mixed Hippocampal Cultures
One of the defining characteristics of the brain is its plasticity, which is the ability to alter and reorganize neuronal circuits. The brain is constantly being shaped and moulded by the external world through endogenous ...
Pharmacological Modulation Of Recombinant Human Two-Pore Domain K+ Channels : Whole-Cell patch-Clamp Analysis
Background potassium currents play an important role in the regulation of the resting membrane potential and excitability of mammalian neurons. Recently cloned two- pore domain potassium channels (K2p) are believed to ...
Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK
A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host ...
Structural Studies On Three-Fold Symmetric Plant Lectins
Lectins, multivalent carbohydrate-binding proteins of non-immune origin, have the unique ability to decode the information contained in complex carbohydrate structures of glycoproteins and glycolipids by stereo-specifically ...
Structural Studies On Mycobacterium Tuberculosis Pantothenate Kinase (PanK)
Pantothenate kinase (PanK) is an ubiquitous and essential enzyme that catalyzes the first step in the universal Coenzyme (CoA) biosynthesis pathway. In this step, pantothenate (Vitamin B5) is converted to 4′-phosphopantothenate, ...
Studies On Sesbania Mosaic Virus Asssembly And Structure And Function Of A Survival Protein (SurE) From Salmonella Typhimurium
X-ray crystallography is a powerful method for determining the three-dimensional structures of biological macromolecules at atomic resolution. Crystallography can reliably provide the answer to many structure related ...
Computer Modelling Studies On DNA Triple Helices