The Crystal Form Diversity From Cocrystals To Eutectics: Design, Synthesis, Production And Property Evaluation

Abstract

This thesis aims to design and synthesize organic molecules to generate properties like SHG, ferroelectric and dielectric. In continuation, we have done cocrystallization studies to study the trend in between the two extremums and also evaluated the particle size as well as the particle size distribution and paved the way for the bulk production in quick time using a thermal inkjet printer. Also, we have studied and analyzed the priorities of hydrogen bond and halogen bond formation involving organic fluorine.

Chapter 1 discusses the multi-component adducts of benzoic acid with differently substituted fluorobenzoic acid combinations to study the trend from solid solutions to cocrystals. The emphasis is on obtaining fundamental insights into the unusual behaviour of organic fluorine's when they are combined with benzoic acid. Chapter 2 proposes a new printing protocol to produce organic "cocrystals, eutectics, solid solutions" of interest using a thermal inkjet printer. The reduction in particle size and uniform particle size distribution have been evaluated in the multi-component adducts of API “Metronidazole”. Chapter 3 describes the preferences of Halogen Bonding and Hydrogen Bonding in selectively designed "4- halophenyl 4' -halo-2',3',5',6'-fluorobenzamides". The halogen bond's strength is varied by incorporating different halogens, and its effect on packing has been studied. Chapter 4 focuses on synthesis of N-benzylidineaniline analogues and connect them to the material applications like second harmonic generation, ferroelectric, and dielectric properties. The analysis and quantification of disorder in the nitro derivative and concomitant polymorphism in hydroxy derivative are crystallographically resolved by using single-crystal XRD technique.