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dc.contributor.advisorChakraborty, Tushar Kanti
dc.contributor.authorKhan, Hina Parveen Afzal
dc.date.accessioned2020-03-13T05:15:05Z
dc.date.available2020-03-13T05:15:05Z
dc.date.submitted2019
dc.identifier.urihttps://etd.iisc.ac.in/handle/2005/4382
dc.description.abstractThe research work delineates a flexible and novel route for the diastereoselective construction of diversely substituted N-heterocyclic variants as valuable scaffolds for natural products and pharmaceuticals, starting from an easily accessible prochiral α-phenyl-β-enamino ester. By taking advantage of the Cp2TiCl-mediated reductive epoxide opening-cyclization, an expedient and unified approach has been accomplished to gain access to a handful of iridoid monoterpenes in an enantiomerically divergent manner starting from (+)-β-citronellene. Also, a radical approach to build oxa-quaternary centers, structural feature of various natural-products-inspired synthons have been undertaken via Cp2TiCl-mediated reductive epoxide opening-cyclization protocol. Furthermore, the feasibility of Cp2TiCl-promoted radical cyclization has also been explored onto N-tethered epoxy indoles which provide an efficient route for the construction of pyrrolo/piperidino[1,2-a]indole derivatives.en_US
dc.language.isoen_USen_US
dc.rightsI grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertationen_US
dc.subjectoxa-quaternary centersen_US
dc.subjectNatural productsen_US
dc.subjectα-phenyl-β-enamino esteren_US
dc.subjectCp2TiClen_US
dc.subjectMitsunobu-Michael reaction sequenceen_US
dc.subject.classificationResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesisen_US
dc.titleA Mitsunobu-Michael Reaction Sequence to N-Heterocyclic Variants and Ti(III)-Mediated Synthesis of Terpenoids and N-Fused Indolesen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.grantorIndian Institute of Scienceen_US
dc.degree.disciplineFaculty of Scienceen_US


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