Show simple item record

dc.contributor.advisorChakravarty, Akhil R
dc.contributor.authorPrasad, Puja
dc.date.accessioned2018-04-11T05:19:14Z
dc.date.accessioned2018-07-30T15:02:00Z
dc.date.available2018-04-11T05:19:14Z
dc.date.available2018-07-30T15:02:00Z
dc.date.issued2018-04-11
dc.date.submitted2013
dc.identifier.urihttp://etd.iisc.ac.in/handle/2005/3379
dc.identifier.abstracthttp://etd.iisc.ac.in/static/etd/abstracts/4245/G25840-Abs.pdfen_US
dc.description.abstractThe present thesis deals with different aspects of the chemistry of oxovanadium(IV) complexes, their interaction with double stranded DNA, photo-induced DNA cleavage, photo-enhanced cytotoxicity in visible light and red light and localisation and cellular uptake to understand the mechanism of cell death. Chapter I presents a general introduction on potential of transition metal complexes as photochemotherapeutic agents. A brief introduction about Photodynamic Therapy (PDT) as a new alternative to chemotherapy for treating cancer has been made. Various modes of interaction of small molecules with duplex DNA are described. Recent reports on metal-based photocytotoxicity, photo-induced DNA cleavage activity and cellular localization are presented in detail. Objective of the present investigation is also dealt in this Chapter. Chapter II of the thesis deals with the synthesis, characterization, DNA binding and photo-induced DNA cleavage activity of ternary oxovanadium(IV) complexes of ONO-donor 2-(2-hydroxybenzylideneamino)phenol (salamp) and phenanthroline bases to explore the photo-induced DNA cleavage activity in UV-A light of 365 nm and photocytotoxicity in visible light. Chapter III deals with the photo-induced DNA cleavage and photocytotoxicity of ternary oxovanadium(IV) complexes containing ONN-donor N-2-pyridylmethylidine-2-hydroxyphenylamine (Hpyamp) Schiff bases and phenanthroline bases. The objective of this work is to investigate the photo-induced DNA cleavage activity in near-IR light. Photocytotoxicity and cell cycle arrest have been studied in HeLa cancer cells. Chapter IV deals serendipitous discovery of planar triazinuim cationic species by vanadyl-assisted novel ring cyclization reaction. The compounds are synthesised, characterized and their DNA binding and anaerobic photoinduced DNA cleavage activity are presented. The importance of the thiazole moiety in the triazinuim species in cellular uptake has been investigated. Photocytotoxicity, localization and cell death mechanism have been studied in HeLa and MCF-7 cells. Chapter V describes the synthesis, characterization, DNA binding, photo-induced DNA cleavage activity and photocytotoxicity of oxovanadium(IV) complexes containing 2-(1H-benzimidazol-2-yl)-N-(pyridin-2-ylmethylene)ethaneamine (Hpy-aebmz) and curcumin as photosensitizer. The effect of conjugating naphthalimide on Hpy-aebmz on photoinduced DNA cleavage and photocytotoxicity has been studied. Cellular uptake, localization and mechanism of cell death induced by complexes have been investigated. Chapter VI presents ternary oxovanadium(IV) complexes having, 2-((1H-benzimidazol-2-yl)methylimino-methyl)phenol (Hsal-ambmz) and phenanthroline bases. The complexes were synthesized, characterized and their DNA binding property studied. Photo-induced DNA cleavage activity and photocytotoxicity in red light has been discussed. Anthracene has been conjugated to a tridentate ligand to investigate cellular uptake, localization and cell death mechanism. Mitochondria targeting property of the complexes having dipeptide has been studied and compared with clinically used drug Photofrin®. The references have been compiled at the end of each chapter and indicated as superscript numbers in the text. The complexes presented in this thesis are represented by bold-faced numbers. Crystallographic data of the complexes, characterized structurally by single crystal X-ray crystallography, are given in CIF format in the enclosed CD (Appendix-I). Due acknowledgements have been made wherever the work described is based on the findings of other investigators. Any unintentional omission that might have happened due to oversight or mistake is regretted.en_US
dc.language.isoen_USen_US
dc.relation.ispartofseriesG25840en_US
dc.subjectOxovanadium Complexesen_US
dc.subjectMetal Based Anticancer Agentsen_US
dc.subjectOxovanadium Complexes - DNA Photocleavageen_US
dc.subjectPhotocytotoxicityen_US
dc.subjectOxovanadium Complexes - DNA Bindingen_US
dc.subjectNearIR-Light Photocytotoxic Oxovanadium Complexesen_US
dc.subjectCellular Localizationen_US
dc.subjectOxovanadium Complexes - Photocytotoxicityen_US
dc.subjectTransition Metal Complexes - Photochemotherapeutic Agentsen_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectTransition Metal Anticancer Agentsen_US
dc.subjectOxovanadium(IV) Schiff Base Complexesen_US
dc.subjectPlanar Triazinuium Cationic Speciesen_US
dc.subjectDNA Cleavage Activityen_US
dc.subjectCancer - Treatmenten_US
dc.subjectOxovanadium(IV) Complexesen_US
dc.subjectNIR-light Induced DNA Cleavageen_US
dc.subject.classificationMedicinal Chemistryen_US
dc.titleStudies on Near-IR Light Photocytotoxic Oxovanadium Complexesen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.disciplineFaculty of Scienceen_US


Files in this item

This item appears in the following Collection(s)

Show simple item record