Browsing Department of Bioengineering (BE, Earlier known as BSSE) by Subject "Research Subject Categories::TECHNOLOGY::Bioengineering"
Now showing items 1-16 of 16
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4D Printing of Polymer Composites to Engineer Resorbable and Deployable Implants
Medical implants include products that are used to replace or restore the function of any damaged organ or tissue inside the body. The current generation of implants are mostly made from non-degradable materials and are ... -
Bacterial cellular heterogeneity in inducible gene expression and drug susceptibility
Biological processes are inherently noisy, and such stochasticity can result in significant cell to cell variability in isogenic bacterial populations. Functionally, cellular heterogeneity can have significant impact on ... -
Biophysics of focal adhesion and cytoskeletal remodeling under fluid shear
Mechanosensors play a vital role in how cells respond to external forces, impacting cell-substrate adhesions through integrin clustering and focal adhesion formation associated with actomyosin contractility. Adhesions ... -
Characteristics of neutrophils and monocyets in patients with end stage kidney disease and those undergoing hemodialysis
Chronic kidney disease is characterised by irreversible impairment of kidney function due to compromise in glomerular filtration. Clinical presentation progresses from asymptomatic initial stages to end stage kidney ... -
Cues for phagosome maturation deciphered using a tuneable particulate system
Phagocytosis, an essential component of the innate immune response, is followed by the process of phagosome maturation inside the cell. Maturation ensures that the engulfed target is delivered to the acidic lysosome for ... -
Design and Development of a Semi-automated System for Electro-thermo-mechanical (Etm) Phenotyping of Breast Tissues Ex-vivo
Breast cancer currently accounts for 25% of all cancers diagnosed in women globally. The conventional confirmatory diagnosis of breast cancer involves histological analysis using hematoxylin and eosin (H&E) staining, ... -
Engineering 3D Organotypic Models for the Study of Breast Cancer Metastasis
Breast cancer is the most common form of cancer among women the world over. Metastasis, or, the spreading of the primary tumor to other vital organs, is the major cause of mortality in breast cancer. Metastasis is a ... -
Experimental and computational approaches to understand collective behaviors of bacterial pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ... -
Immune cell surveillance and death on silicone catheter surfaces drives bacterial biofilm formation
Silicone venous catheters are among the most used medical devices in the world with a prevalence of up to 80% in hospitalised patients. While they are used for several life-saving applications, they are also prone to ... -
Improving Healing Outcomes in Diabetic Wounds by Understanding and Modulating Immune Responses
Diabetic Foot Ulcers (DFUs) are chronic wounds that show delayed or absence of healing in individuals with diabetes. Currently, diabetic wounds are managed clinically through regular debridement, pressure off-loading, ... -
Intra- and inter-cellular drivers of Epithelial-Mesenchymal heterogeneity in cancer cells
Phenotypic heterogeneity is a fundamental feature reported across prokaryotic and eukaryotic cells. This heterogeneity enables an isogenic cell population to be composed of distinct subpopulations with varying functional ... -
Investigations into the changes in biomechanics of liver cells upon HCV infection
Biomechanics is an important regulator of cell function. Active (external forces) as well as passive (substrate stiffness) mechanical stimuli from the cell microenvironment can alter fundamental aspects of cell function ... -
Micro-carriers mediated bacteriophage delivery for targeting intracellular Mycobacterium tuberculosis infection and TB prevention
Tuberculosis (TB) is a debilitating infectious disease that afflicts 10 million people every year. Treatment is particularly challenging due to prolonged treatment duration (4-6 months) consisting of an oral regimen of 4 ... -
New Dimension in Senescence: Unraveling Cellular Senescence in Three-Dimensional Scaffolds
Aging is a ubiquitous process that results in the progressive and irreversible loss of function. It is induced by accumulating damage caused by a variety of stressors, both internal and external. Although the advancement ... -
PLGA Based Drug Carriers for Treatment of Osteoarthritis
Osteoarthritis (OA) has affected nearly 22-39% of the Indian population and remains one of the most common musculoskeletal disorders that affects articular joints. Post-traumatic osteoarthritis, which develops following ... -
Role of Fiber Orientations in the Mechanobiology of Cells under Stretch
Fiber reinforcement plays an important role in the structure and function of biological materials. Soft connective tissues in human body like artery, heart tissues, skin etc. exhibit anisotropic material responses due to ...