Browsing Centre for Biosystems Science and Engineering (BSSE) by Subject "Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS"
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Analysis of vocal sounds in asthmatic patients
Around 334 million people have asthma worldwide. Asthma is an inflammatory disease of the airways which causes cough, breathlessness, chest tightness, and other peculiar sounds during breathing. The golden standard test ... -
Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis
Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ... -
Dynamical systems biology approach to identify mediators of the Epithelial-Hybrid-Mesenchymal spectrum
Cancer metastasis – the spread of cancer cells from one organ to another – remains the major cause of cancer-related deaths. A hallmark of metastasizing cells is their ability to adapt quickly and reversibly to their dynamic ... -
Engineering Disease Models for Cardiac and Skeletal Muscle Tissues
Biomedical research aims to gain deeper insights into the mechanisms of human pathophysiology to develop improved therapies and diagnostics. Despite significant advances made in the understanding and treatment of human ... -
Experimental and computational approaches to understand collective behaviors of bacterial pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ... -
Functional regulation of cytoplasmic dynein in vivo
In the crowded confines of the eukaryotic cell, where large cargo (> 100 nm) are diffusionaly constrained, intracellular transport by motor proteins plays a crucial role in the exchange of material between various compartments ... -
Helical Magnetic Nanomotors Fabrication, Toxicity and Therapeutics
The 21st century dawned with remarkable advances in the controlled motion of nanoparticles. These particles could be manipulated through external energy sources (chemical, magnetic, acoustic, or biological), resulting in ... -
Integrating Computational Tools and Models to Study Positive-sense RNA Virus Lifecycle
Positive-sense single-stranded RNA ((+)RNA) viruses pose significant challenges to public health. Notable families such as Enteroviridae, Flaviviridae, and Coronaviridae have caused epidemics (Dengue, Poliomyelitis, Zika) ... -
Resolvin D1-loaded Liposomal Nanocarriers for the Treatment of Osteoarthritis
Osteoarthritis (OA) is the most common disorder of the joints and currently affects >300 million patients worldwide. In this disease, the articulating cartilage undergoes progressive damage which leads to severe pain and ... -
Towards a Better Understanding of the Interaction between Phagocytic Immune Cells and Synthetic Particulates
Particulate technology has transformed the field of diagnostic and therapeutic medicine due to the ability of particulates to provide better contrast in various imaging modalities and improve the targeting of therapeutic ...