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Functional regulation of cytoplasmic dynein in vivo
In the crowded confines of the eukaryotic cell, where large cargo (> 100 nm) are diffusionaly constrained, intracellular transport by motor proteins plays a crucial role in the exchange of material between various compartments ...
Diabetogenesis and Albumin Molecular Modifications Newer Biological Insights and Clinical Implications
To address the many unmet scientific needs in diabetes care (pathogenesis pathways, earliest diagnosis, efficient monitoring, safer and better therapies and importantly prevention approaches), our research focussed on: (a) ...
Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis
Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ...