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The Mechanism Of Fragility Of The BCL2 And HOX11 Breakpoint Regions During t(14;18) And t(10;14) Chromosomal Translocations In Lymphoid Cancers
(2014-08-05)
Haematological cancers like leukemia and lymphoma are characterized by genetic abnormalities, specifically chromosomal translocations. Analyses of the translocation breakpoint regions in patients have shown that some loci ...
Identification Of Key DNA Elements Involved In promoter Recognition By Mxr1p , A key Regulator Of Methanol Utilisation Pathway In Pichia Pastoris
(2010-04-09)
The methylotrophic yeast Pichia pastoris is widely used for recombinant protein production due to its ability to grow to high cell densities as well as possession of an inducible methanol utilization pathway (MUT). The ...
Insights Into Transcription-Repair Coupling Factor From Mycobacterium Tuberculosis
(2014-12-01)
Introduction
Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions. One of the well characterized NER systems is from E. coli which ...
Mechanism Of RAG Action As A Structure-Specific Nuclease : Implications In Genomic Instability In Lymphoid Cells
(2013-07-18)
Recombination Activating Genes (RAGs) orchestrate the process called V (D) J recombination, which enables the vertebrate adaptive immune system to specifically recognize millions of antigens. During this recombination ...
Processing Of DNA Recombination And Replication Intermediates By Mycobacterium Tuberculosis RuvA And RuvB Proteins
(2013-06-14)
Homologous recombination (HR) is a highly conserved cellular process involved in the
maintenance of chromosomal integrity and generation of genetic diversity. Biochemical and genetic studies have suggested that HR is ...
Helicobacter Pylori Restriction-Modification Systems : Possible Roles Beyond Genome Protection
(2013-06-06)
Helicobacter pylori is one of the most potential and successful human pathogen which colonizes atleast 50% of world population. One of the important characteristics of this pathogen is the degree of allelic diversity and ...
Studies On DNA Mismatch Repair Nicking Endonucleases Of Haemophilus Influenzae And Neisseria Gonorrhoeae
(2010-01-01)
DNA mismatch repair ensures faithful transmission of genetic material from parents to progeny, which is required for the survival of the organism. The studies on E. coli MMR proteins have formed the basis for the study ...