Now showing items 1-10 of 18
The Mechanism Of Fragility Of The BCL2 And HOX11 Breakpoint Regions During t(14;18) And t(10;14) Chromosomal Translocations In Lymphoid Cancers
Haematological cancers like leukemia and lymphoma are characterized by genetic abnormalities, specifically chromosomal translocations. Analyses of the translocation breakpoint regions in patients have shown that some loci ...
Processing Of DNA Recombination And Replication Intermediates By Mycobacterium Tuberculosis RuvA And RuvB Proteins
Homologous recombination (HR) is a highly conserved cellular process involved in the maintenance of chromosomal integrity and generation of genetic diversity. Biochemical and genetic studies have suggested that HR is ...
Insights Into Transcription-Repair Coupling Factor From Mycobacterium Tuberculosis
Introduction Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions. One of the well characterized NER systems is from E. coli which ...
Biochemical Characterization Of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 Using Telomeric DNA : A Role For The Endonucleolytic Activity Of Mre11 In Telomere Length Maintenance And Its Regulation By Rad50
Meiotic recombination is a prerequisite for exchange of genetic information in all Sexually reproducing organisms. This process is initiated by the formation of double stranded breaks (DSBs) in DNA followed by homology ...
Selective Binding Of Meiosis-Specific Yeast Hop1 Protein, or Its ZnF Motif, To The Holliday Junction Distorts The DNA Structure : Implications For Junction Migration And Resolution
Saccharomyces cerevisiae HOP1, which encodes a component of the synaptonemal complex, plays an important role in both gene conversion and crossing over between homologs, as well as enforces the meiotic recombination ...