Now showing items 11-14 of 14
Characterization of the Cis and Trans Acting Factors that Influence p53 IRES Function
p53 is a nodal tumor suppressor protein that acts as a major defense against cancers. Approximately 50% of human tumours have mutations in p53 gene. Among its myriad features, the most distinctive is the ability to elicit ...
Molecular Phenotyping of Mutations in Guanylyi Cyclase C Associated with Congenital Diarrhea
Guanylyl cyclase C (GC-C) is a member of particulate guanylyl cyclases, discovered primarily as the target of a family of heat stable enterotoxins (ST), produced by enterotoxigenic Escherichia coli (ETEC). ST is acknowledged ...
Solution Structure Studies on the Effects of Aromatic Interactions and Cross-Strand Disulfide Bonds on Protein Folding
The work presented in this thesis focusses primarily on the determination of protein structure at atomic resolution, with NMR spectroscopy as the principle investigative tool. The thesis is divided into four parts. Part I ...