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Guanylyl Cyclase C Regulation And Pathophysiology
(2015-02-26)
The survival of the any living organism depends on its availability to communicate, and a breakdown of cellular signaling can have dire consequences such as uncontrolled cellular proliferations or even cell death. Environmental ...
Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling
(2015-08-19)
Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies ...
Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Triggered TLR2 Signaling : Implications For Immune Evasion Strategies
(2015-09-04)
Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Host immune responses during mycobacterial infection involve potent cell effector functions including ...
Investigations On The Role Of The Global Regulator H-NS In The Survival Of Escherichia Coli In Stationary-Phase
(2015-08-17)
Studies on stationary phase cultures of microorganisms in the laboratory have helped us understand the genetic and physiological basis of adaptation in their natural habitats. Stasis or decline in bacterial populations due ...
Computational Analyses Of Proteins Encoded In Genomes Of Pathogenic Organisms : Inferences On Structures, Functions And Interactions
(2015-02-04)
The availability of completely sequenced genomes for a number of organisms provides an opportunity to understand the molecular basis of physiology, metabolism, regulation and evolution of these organisms. Significant ...
Transcription In Mycobacteria : From Initiation To Elongation
(2015-01-02)
The global re-emergence of TB and other mycobacterial infections have underscored the need for a thorough investigation of the biology of the causative agent, Mycobacterium tuberculosis, at the molecular level. The peculiar ...
Cyclic AMP-Regulated Protein Lysine Acetylation In Mycobacteria
(2015-07-17)
Tuberculosis continues to be one of the major causes of morbidity and mortality worldwide. Several mycobacterial species such as M. tuberculosis and M. africanum are responsible for causing this disease in humans. Reports ...
Structural Studies On Pyridoxal 5'-Phosphate Dependent Enzymes Involved In D-Amino Acid Metabolism And Acid Tolerance Reponse
(2015-08-19)
Metabolism of D-amino acids is of considerable interest due to their key importance in cellular functions. The enzymes D-serine dehydratase (DSD) and D-cysteine desulfhydrase (DCyD) are involved in the degradation of D-Ser ...
Insights Into Molecular Regulation Of Cardiomyocyte Differentiation Of Mouse Pluripotent Stem Cells
(2015-08-03)
Pluripotent stem cells (PSCs) are specialized cells, which have remarkable ability to maintain in an undifferentiated state and are capable of undergoing differentiation to three germ-layer lineage cell types, under ...
Designed Synthetic Peptides : Models For Studies Of Conformational Transitions And Aromatic Interactions
(2015-07-17)
This thesis set out to explore the conformational properties of short designed peptide sequences, in which transitions between structural states may be anticipated. The use of conformationally constrained residues like ...