Now showing items 1-10 of 153
Structural Studies On Three-Fold Symmetric Plant Lectins
Lectins, multivalent carbohydrate-binding proteins of non-immune origin, have the unique ability to decode the information contained in complex carbohydrate structures of glycoproteins and glycolipids by stereo-specifically ...
Computer Modelling Studies On DNA Triple Helices
Structural, Biophysical And Biochemical Studies On Mannose-Specific Lectins
For a long time, the scientific community underestimated the value of carbohydrates and the approach of most scientists to the complex world of glycans was apprehensive. The scenario, however, has changed today. With the ...
Orienting Macromolecule At The Air - Water Interface : DNA-Protein Interaction On Langmuir Films
The Langmuir – Blodgett (LB) technique is about forming insoluble monolayer on the surface of aqueous solution and recently, it has emerged as one of the best method to study floating monolayer at the air – water interface. ...
DNA Gyrase And Topo NM From Mycobacteria : Insights into Mechanism And Drug Action
Maintenance of a topological homeostasis by introduction and removal of the supercoils to relieve excessive strain on the DNA is a hallmark of topoisomerase function in the cell. The requirement of the topoisomerases during ...
Studies on Interactions between ARE Binding Proteins and Splicing Factors and their Role in Altered Splicing of PDGF-B ORF
Pre-mRNA splicing is an important level in posttranscriptional gene regulation that is essential for accurate protein synthesis and generating protein diversity. The abundance of cryptic splice sites and long intronic DNA ...
Conformational Analysis And Design Of Disulfides In Antiparallel β-Sheets And Helices
Disulfides are the primary covalent interactions within a protein molecule that connect residues which are sequentially distant. Naturally occurring disulfides enhance the stability of the protein by destabilization of ...
Cell Survival Strategies : Role Of Gyrase Modulatory Proteins
A steady state level of negative supercoiling is essential for chromosome condensation, initiation of replication and subsequent elongation step. DNA gyrase, found in every eubacteria, serves the essential housekeeping ...