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    Pranlukast as an Allosteric Inhibitor of M.Tuberculosis Ornithine Acetyltransferase : Implication Towards Novel Combinatorial Therapy 

    Mishra, Archita
    Tuberculosis (TB) is a deadly disease responsible for the death of approximately 1.5 million people each year, with the highest being from developing nations. Tuberculosis affects mostly the lungs, and other parts of the ...

    Design and Characterization of HIV-1 ENV Derived Immunogens 

    Purwar, Mansi (2018-06-21)
    The Human Immunodeficiency Virus (HIV) is a member of the retroviridae family from lentivirus genus which primarily infects CD4+ T cells and also to lesser degree monocytes, macrophages, and dendritic cells causing progressive ...

    Secondary Structures in Proteins : Identification and Analyses 

    Kumar, Prasun (2018-07-12)
    Proteins are large biomolecules consisting of one or more long chains of amino acid residues. They perform a vast array of functions within living organisms. In this thesis, we present analyses of different secondary ...

    G-Protein Coupled Estrogen Receptor (hGPER)- Mediated Action of 17β-Estradiol on hTREK-1 Potassium Channel 

    Choudhury, Nasreen
    TREK-1 is a two-pore domain potassium channel that contributes to maintenance of the resting membrane potential of a cell. TREK-1 is involved in several physiological and pathophysiological conditions like nociception, ...

    HIV-1 Immunogen Design : Envelope Protein Minimization, Stabilization and Glycan Removal 

    Rathore, Ujjwal
    Effective vaccines exist for a number of viral diseases. However, despite much effort, there is no successful vaccine against the Human Immunodeficiency Virus (HIV-1). The envelope glycoprotein (Env) of HIV-1 gp120, the ...

    Role of Lactate and TREK1 Channels in Neuroprotection during Cerebral Ischemia – in Vitro Study in Rat Hippocampus 

    Banerjee, Aditi (2017-12-16)
    Cerebral ischemia is a highly debilitating condition where shortage of oxygen and glucose leads to profuse cell death. Insufficient blood supply to the brain leads to cerebral ischemia and increase in extracellular lactate ...

    Structural and Functional Studies on the Mycobacterium tuberculosis σ factor σJ 

    Goutam, Kapil (2018-05-21)
    Regulation of transcription in prokaryotes is primarily governed at the transcription initiation step. This feature has been extensively characterized in model prokaryotes notably Escherichia coli and Bacillus subtilis. ...

    Structural and Functional Characterisation of Small Heat Shock Protiens from Mycobacterium Marinum M 

    Bhandari, Spraha
    Small Heat Shock Proteins (sHSP) are ATP-independent molecular chaperones that exhibit diversity in structure, function and mode of action. They are present ubiquitously in all kingdoms of life. They function mainly by ...

    Computational Analyses of Protein Structure and Immunogen Design 

    Patel, Siddharth (2018-08-20)
    The sequence of a polypeptide chain determines its structure which in turns determines its function. A protein is stabilized by multiple forces; hydrophobic interaction, electrostatic interactions and hydrogen bond formation ...

    Solution Structures and Dynamics of Conotoxins and Small MutS Related Domain from Helicobacter Pylori MutS2 

    Kumar, Kancherla Aswani (2018-06-08)
    The work presented in this thesis describes the determination of structures of peptides and proteins at atomic resolution. Nuclear Magnetic Resonance (NMR) spectroscopy was used as the principal method of investigation. ...
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    AuthorAditya Kumar, * (1)Ashhad, Sufyan (1)Baloni, Priyanka (1)Bandyopadhyay, Debarati (1)Banerjee, Aditi (1)Banerjee, Sanchari (1)Bangalore, Disha Mohan (1)Bangera, Mamata (1)Bhandari, Spraha (1)Bharambe, Nikhil Govind (1)... View MoreSubject
    Molecular Biophysics (64)
    Mycobacterium smegmatis (5)Hippocampus (4)HIV-1 gp120 (4)(p)ppGpp (3)CcdB (3)Mycobacteria (3)Astrocytes (2)Bacterial Pathogens (2)Bacterial Proteins (2)... View MoreDate Issued2018 (37)2017 (1)Has File(s)Yes (64)

    etd@IISc is a joint service of SERC & J R D Tata Memorial (JRDTML) Library || Powered by DSpace software || DuraSpace
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