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Understanding Phage MU Mom Regulation and Function
(2018-06-11)
Mu is a temperate bacteriophage which infects Escherichia coli and several other Gram negative enteric bacteria. It is an extraordinary phage in several respects and has carved a special niche for itself both as a genetic ...
Wnt/β-Catenin-dependent Epigenetic Factors Shape Host Immune Responses During Mycobacterial Infection
The genus mycobacterium has more than 120 species of bacteria; one being M. tuberculosis (Mtb), the etiological agent of tuberculosis (TB). During infection, the host mounts a heightened immune response to contain the ...
Functional Insights into the Canonical and Non-canonical Roles of the Fission Yeast Splicing Factor SpPrp16
The spliceosome is a large multi-megadalton RNA-protein machine which facilitates the
removal of introns from eukaryotic nascent pre-mRNAs by two concerted
transesterification reactions. The spliceosome is comprised of ...
Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
(2018-05-09)
HCV genome is a positive sense single-stranded RNA containing a single open reading frame (ORF) flanked by untranslated regions (UTRs), 5’UTR and 3’UTR.Initiation of HCV RNA translation is mediated by internal ribosome ...
Exploring the Unusual Properties and Non-canonical Roles of Promiscuous Restriction Endonuclease KpnI
Restriction modification (RM) systems are important components of bacterial immune system. Their primary function is to protect the bacteria from invading bacteriophages. Based on the subunit composition, enzyme properties ...
Functional Insights into PRR-Driven SHH Signaling : Implications for Host-Microbial Interactions
(2018-07-26)
Mycobacterium are important human pathogens and their strength lies in establishing acute infections, latent infections as well as co-existing with other dreadful infectious agents like HIV. The success of mycobacterium ...
Delineating the Roles for WNT Signaling During PRRs Driven Inflammatory Responses : Implications for Host-Pathogen Interaction
The mammalian immune system consists of the innate and adaptive arm/s that protect the host against pathogenic infections in a highly coordinated process involving multiple steps. Innate immune cells such as macrophages ...
Regulation of Expression of p53 and its Isoform Δ40p53 : Consequences on Cellular Gene Expression
The TP53 tumour suppressor gene encodes for p53 protein which is the frequently altered gene in most of the cancers. p53 protein is activated in response to different stresses and plays major role in maintaining genome ...
Regulation of Host Innate Immune Responses by Hippo Signaling Pathway during Pattern Recognition Receptors (PRRs) Driven Inflammation : Implication for Host-Pathogen Interactions
Innate immunity refers to the first line of defence system of the host that comes into play immediately or within hours of appearance of invading pathogens like bacteria, viruses and fungi. Cells of the innate immune system ...
Enterovirus Non-structural Protein 3A Interactions with Sec12, an upstream Component of the COPII Secretory Pathway and Implications for Viral Replication
(2018-07-20)
Polioviruses, Coxsackieviruses, and Echoviruses belonging to the Picornaviridae family of positive-stranded, non-enveloped viruses, are highly infectious and associated with a range of illnesses in children from minor ...